This screenshot is from a UBRS run. Esa has her primary attack buttons on the left, shields in the middle, and healing on the right. Blessings are on the left, using option-#. As you can see, I'm having trouble managing seals at the moment. I don't lock my hotkeys, because I will move things around quite frequently. You might notice in the shot, I've accidentally displaced Blessing of Freedom, since it's supposed to be next to Blessing of Sacrifice. Blessings go in order from on-myself, to second in the party, then third and so on. Seals will change depending on the situation. When we got into the next room, Seal of Wisdom and Light went on the primary attack buttons, displacing Fury and Command. I use the number pad very frequently, and am more comfortable with it than the righthand side of the regular number keys. I've considered changing everything around so I use the number pad more often, but it would take a lot of retraining. Oh and another small point: I've been trying to train myself to use 8 9 0 for healing... but I've been using 9 for Consecration too much. Recently I had to change it back, because I can't seem to train myself to hit any other key. So in Scholomance, I was trying to Consecrate and kept hitting Flash Heal. Very confusing.

So as you can see, my keymaps are still a work in progress. Right now I only use the Gatherer and Atlas mods, though I would like to install Whispercast as well. Overall I'm pretty happy with the native UI (wasn't before, but am now). There are a lot of mods to add on "nice-to-have" things, but I haven't found the need to add any more mods born from "necessity," aside from those I mentioned. And truthfully, those I have now are there because I've become impatient and not because they're required.